By Xiuling Lu

Published in: Pharmaceutical online

Published on: February 9, 2023

Introduction: Most nanoparticle formulations are in solution with a heterogeneous size distribution. These nanosuspensions can be unstable and subject to problems, such as sedimentation, agglomeration, crystal growth or chemical reactions. Lyophilization can increase the stability of these particles, which also benefits the stability of the drug products incorporated in them.

Recently, Dr. Xiuling Lu, University of Connecticut, presented a webinar describing the challenges of freeze-drying nanoparticles and how, in collaboration with Dr. Robin Bogner Ph.D., her group has designed and evaluated solutions to lyophilizing LNPs. This tech note summarizes the webinar and includes a selection of questions from the Q&A session.

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